Endocrine Abstracts

Chronic inflammation in adipose tissue contributes to obesity-related insulin resistance. The 3-Phosphoinositide-dependent Protein Kinase 1 (Pdk1)/forkhead transcription factor (Foxo1) pathway is important in regulating glucose and energy homeostasis, but little is known about this pathway in adipose tissue macrophages (ATMs). To investigate this, we generated transgenic mice that carried macrophage/granulocyte-specific mutations, including a Pdk1 knockout (LysMPdk1-/-), a Pdk...

Introduction: Anaplastic thyroid carcinoma (ATC) carries an extremely poor prognosis. The reported median survival time is 3-9 months and one year survival rate is 18-20%. Here we report 4 cases of ATC.Case reports: Case 1: An 82 year-old female presented with rapidly progressive anterior neck swelling. She underwent hemi-thyroidectomy and D1 dissection. Pathological diagnosis was ATC, T4aN0. External beam radiotherapy (EBRT) to the whole neck was admini...

Purpose: For vaginoplasty of Rokitansky syndrome, we use oxidized regenerated cellulose instead of bio-craft that has been used in the past because it requires a less invasive and more physiological surgery. However, the mechanism of epithelialization of this procedure is still not clear. There is a report that differentiation and proliferation of the vaginal epithelium of newborn mice is promoted by administration of basic fibroblast growth factor (bFGF).<p class="abstext...

Undiagnosed diabetes and impaired fasting glucose, a condition that increases the risk for diabetes, have important health consequence. About one-third diabetes was undiagnosed. Thus, prevalence estimates based on self-report or doctor diagnosed disease are underestimates of total prevalence of diabetes, which includes individuals with both known and undiagnosed type 2 diabetes. To examine the prevalence of undiagnosed glucose intolerance, we did 75 g oral glucose tolerance te...

Objective: Serum thyroglobulin doubling time (Tg-DT/DR) is a valuable marker for predicting recurrences/metastases and response to treatment in patients with well-differentiated follicular cell-derived thyroid carcinoma. Similarly, tumor-volume doubling time/rate (TV-DT/DR) is helpful in predicting tumor progression during active surveillance of papillary microcarcinoma and chemotherapy. However, no study has investigated the clinical significance of Tg-DT/DR and TV-DT/DR in p...